America is currently the preeminent power. That may change 20 years down the road, but it's unlikely short of WWIII or a civil war to be anything less than a top tier power. China is on the ascendent right now, and may well surpass the US, though it's going to have some demographic issues down the road. Hard to say how well they'll deal with them, but they'll likely be a major power as well. The European nations need to stand together if they want to compete. Space travel is expensive, and none of them alone can fund it. They already realize this- that's why the European space agency exists. Clashing national identites is an issue (see the Euro crisis) but if Europe wants to be relevant, it has to stand together Russia is still significant because it has a ton of nukes and a sizable military industrial complex. The Soviets steamrolling everyone with numbers is a thing of the past, and is unlikely to happen again, because first world countries- which Russia is more or less- don't have the sort of population growth to support that sort of thing. That said a Russian-Indian alliance might make for an interesting power bloc. They already have some joint development programs going, and both might band together in face of an ascendent China. It'd be a bit of an odd couple, but it might work. Africa is unlikely to get's it's act together, but South America might. Brazil is doing fairly well, and might provide the nucleus around which a SA power bloc could form. A South American power bloc is unlikely to be a top power, but it could have a few colonial ventures going. Japan is either going to be in the US's sphere of influence or part of an Oceania centered bloc. I don't think the US, China or EU would particularly care for the formation of such a bloc, but if they're distracted it's possible I suppose.